PT-141 10mg
PT-141 10mg
PT-141 10mg
PT-141 10mg
PT-141 10mg

PT-141 10mg

£20.90

PT-141 is a specialised synthetic melanocortin peptide developed for advanced scientific exploration of melanocortin receptor signalling (MC3R / MC4R) and central neuropeptide pathways, commonly studied in models of motivation, reward, and neuroendocrine signalling.

  • OP Labs formerly Oxford Peptides
  • Batch tested Purity: ≥ 98% (HPLC, typical)
  • CAS Number: 189691-06-3
  • Molecular Formula: C50H68N14O10
SKU: x-35 Category:
  • OP Labs formerly Oxford Peptides
  • Batch HPLC tested at 99%+ purity
  • Store frozen long term or in fridge when ready to be used
  • Sold for research purposes only
  • Contact us for Wholesale Orders

Download COA here: PT-141_COA.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.

PT-141

Synonyms / Designations: PT-141, Bremelanotide, Melanotan II analogue
CAS Number: 189691-06-3
Molecular Formula: C50H68N14O10
Molecular Weight: ~1025.18 g/mol
Peptide Length: 7 amino acids (cyclic peptide)
Peptide Type: Synthetic melanocortin receptor agonist
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 10 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

PT-141 is a synthetic cyclic heptapeptide derived from melanocortin peptides and developed for experimental investigation of melanocortin receptor–mediated signalling pathways. It is structurally related to Melanotan II but exhibits distinct receptor selectivity and signalling characteristics.

In biochemical and cellular research systems, PT-141 interacts primarily with melanocortin receptors (MC1R, MC3R, MC4R), initiating intracellular signalling cascades associated with cAMP production and downstream transcriptional regulation. Experimental studies investigate receptor binding affinity, signalling bias, and comparative behaviour relative to other melanocortin analogues. Observed molecular responses depend on concentration, exposure duration, and experimental model.

Applications in Research

  • As a molecular probe for studying melanocortin receptor signalling
  • Investigation of GPCR-mediated intracellular signalling pathways
  • In vitro studies examining receptor selectivity and peptide stability
  • Use as a reference compound in neuroendocrine and peptide signalling research

Specifications Summary

Purity (HPLC): ≥ 99 %
Appearance: White to off-white lyophilised powder
Molecular Weight: ~1025.18 g/mol
Peptide Type: Synthetic melanocortin analogue
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 10 mg

Handling, Reconstitution & Stability

  • Weigh under dry conditions; peptide is hygroscopic
  • Reconstitute in sterile water or appropriate buffered aqueous solution
  • Avoid vigorous agitation during dissolution
  • Filter sterilize if required prior to use
  • Aliquot and store reconstituted solutions at –20 °C or lower
  • Avoid repeated freeze–thaw cycles

Precautions & Notes

  • Experimental behaviour is influenced by receptor expression, peptide concentration, and exposure duration
  • Buffer composition, pH, and ionic strength may affect peptide stability
  • Appropriate controls are recommended to distinguish receptor-specific effects
  • Intended strictly for laboratory research use

References

Hadley M.E. et al. Melanocortin peptides and receptors. Endocrine Reviews, 1999.
https://pubmed.ncbi.nlm.nih.gov/10447403/

Wessells H. et al. Melanocortin receptor agonists and signalling mechanisms. Journal of Peptide Research, 2003.
https://pubmed.ncbi.nlm.nih.gov/12622733/

Cone R.D. The melanocortin system and GPCR signalling. Nature Reviews Neuroscience, 2006.
https://pubmed.ncbi.nlm.nih.gov/16755264/

Keywords: PT-141, Bremelanotide, Melanocortin Agonist, Synthetic Peptide, GPCR Signalling

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