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Download COA here: Semax_COA.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.

Semax

Synonyms / Designations: Semax, ACTH(4–7) Pro-Gly-Pro, Met-Glu-His-Phe-Pro-Gly-Pro
CAS Number: 80714-61-0
Molecular Formula: C37H51N9O10S
Molecular Weight: ~813.92 g/mol
Peptide Length: 7 amino acids
Peptide Type: Synthetic neuropeptide (ACTH(4–7) analogue)
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 5 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone fragment ACTH(4–7), modified with a C-terminal Pro–Gly–Pro sequence to enhance metabolic stability. It was developed for experimental investigation of neuropeptide signalling, neuromodulation, and central nervous system regulatory pathways.

In biochemical and cellular research systems, Semax has been studied for its interactions with neuronal signalling pathways associated with neurotrophic factors, synaptic plasticity, and stress-response regulation. Experimental models commonly investigate its effects on intracellular signalling cascades, gene expression related to neurotrophins, and modulation of neurotransmitter systems. Observed molecular responses are dependent on experimental design, concentration, and model system.

Applications in Research

• As a molecular probe for studying neuropeptide-mediated signalling pathways.
• Investigation of neuronal plasticity, neurotrophic signalling, and stress-related molecular mechanisms.
• In vitro and in vivo research examining peptide stability and CNS-active peptide analogues.
• Use as a reference compound in neurobiology and peptide signalling research.

Specifications Summary

Purity (HPLC): ≥ 99 %
Appearance: White to off-white lyophilised powder
Molecular Weight: ~813.92 g/mol
Peptide Type: Synthetic ACTH-derived neuropeptide
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic.
• Reconstitute in sterile water or appropriate buffered aqueous solution.
• Avoid vigorous agitation during dissolution.
• Filter sterilize if required (e.g. 0.22 µm) prior to use.
• Aliquot and store reconstituted solutions at –20 °C or lower.
• Avoid repeated freeze–thaw cycles.

Precautions & Notes

• Experimental behaviour of Semax is influenced by neuronal model, receptor expression, peptide concentration, and exposure duration.
• Buffer composition, pH, and ionic strength may affect peptide stability.
• Appropriate controls are recommended to distinguish specific from non-specific effects.
• Intended strictly for laboratory research use; not for human or veterinary application.

References

Ashmarin I.P. et al. Semax as a regulator of neurotrophic factors. Neuroscience and Behavioral Physiology, 1997.
https://pubmed.ncbi.nlm.nih.gov/9404683/

Gusev E.I. et al. Neuropeptide Semax in experimental models of brain function. Neuroscience and Behavioral Physiology, 2000.
https://pubmed.ncbi.nlm.nih.gov/10739407/

Myasoedov N.F. et al. ACTH-derived peptides and central nervous system regulation. Journal of Peptide Science, 2011.
https://pubmed.ncbi.nlm.nih.gov/21491577/

Keywords: Semax, ACTH(4–7), Synthetic Neuropeptide, CNS Signalling, Neurotrophic Peptide